Recreational drug toxicity.

and after study. BMJ 2001;322:1203–7. 2 Khashab M, Tector AJ, Kwo PY. Epidemiology of acute liver failure. Curr Gastroenterol Rep 2007;9:66–73. 3 Davidson DG, Eastham WN. Acute liver necrosis following overdose of paracetamol. BMJ 1966;2: 497–9. 4 Thomson JS, Prescott LF. Liver damage and impaired glucose tolerance after paracetamol overdosage. BMJ 1966;2:506–7. 5 Vale A. Paracetamol (acetaminophen). Medicine 2007 (in press). 6 Bernal W, Donaldson N, Wyncoll D, Wendon J. Blood lactate as an early predictor of outcome in paracetamolinduced acute liver failure: a cohort study. Lancet 2002;359:558–63. 7 Pakravan N, Bateman DN, Goddard J. Effect of acute paracetamol overdose on changes in serum and urine electrolytes. Br J Clin Pharmacol 2007;64:824–32. 8 Vale JA, Proudfoot AT. Paracetamol (acetaminophen) poisoning. Lancet 1995; 346:547–52. 9 O’Grady JG, Wendon J, Tan KC et al. Liver transplantation after paracetamol overdose. BMJ 1991;303:221–3. 10 Seifert SA, Bronstein AC, McGuire T. Massive ibuprofen ingestion with survival. J Toxicol Clin Toxicol 2000;38:55–7. 11 Smolinske SC, Hall AH, Vandenberg SA, Spoerke DG, McBride PV. Toxic effects of nonsteroidal anti-inflammatory drugs in overdose. An overview of recent evidence on clinical effects and dose-response relationships. Drug Saf 1990;5:252–74. 12 Goddard J, Stachan FE, Bateman DN. Urinary sodium and potassium excretion as measures of ibuprofen nephrotoxicity. J Clin Toxicol 2003;41:747. 13 Flomenbaum NE. Salicylates. In: Flomenbaum NE, Howland MA, Hoffman RS. Goldfrank’s toxicologic emergencies, 8th edn. London: McGraw-Hill Professional, 2006. 14 Afshari R, Good AM, Maxwell SR, Bateman DN. Co-proxamol overdose is associated with a 10-fold excess mortality compared with other paracetamol combination analgesics. Br J Clin Pharmacol 2005;60:444–7.